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Design of multivalent-epitope vaccine models directed toward the world’s population against HIV-Gag polyprotein: Reverse vaccinology and immunoinformatics

27 Sept 2024

Abstract excerpt

Significant progress has been made in HIV-1 research; however, researchers have not yet achieved the objective of eradicating HIV-1 infection. Accordingly, in this study, eucaryotic and procaryotic in silico vaccines were developed for HIV-Gag polyproteins from 100 major HIV subtypes and CRFs using immunoinformatic techniques to simulate immune responses in mice and humans. The epitopes located in the conserved...

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PMID: 39331650
DOI: 10.1371/journal.pone.0306559

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