Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups.

doi:10.2337/db10-0177

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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups.

Diabetes - 1 Oct 2010

Freathy Rachel M, Hayes M Geoffrey, Urbanek Margrit, Lowe Lynn P, Lee Hoon, Ackerman Christine, Frayling Timothy M, Cox Nancy J, Dunger David B, Dyer Alan R, Hattersley Andrew T, Metzger Boyd E, Lowe William L

Abstract excerpt

OBJECTIVE: Common genetic variants in GCK and TCF7L2 are associated with higher fasting glucose and type 2 diabetes in nonpregnant populations. However, their associations with glucose levels from oral glucose tolerance tests (OGTTs) in pregnancy have not been assessed in a large sample. We hypothesized that these variants are associated with quantitative measures of glycemia in pregnancy. RESEARCH DESIGN AND...

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PMID: 20682688
DOI: 10.2337/db10-0177
PMCID: PMC3083839

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