Article
Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.
Diabetes - 1 Feb 2005
Weedon Michael N, Frayling Timothy M, Shields Beverley, Knight Beatrice, Turner Tina, Metcalf Bradley S, Voss Linda, Wilkin Terence J, McCarthy Anne, Ben-Shlomo Yoav, Davey Smith George, Ring Sue, Jones Richard, Golding Jean, Byberg Liisa, Mann Vera, Axelsson Tomas, Syvänen Ann-Christine, Leon David, Hattersley Andrew T
Abstract excerpt
Rare mutations in the glucokinase (GCK) gene cause fasting hyperglycemia and considerably influence birth weight when present in a mother or her offspring. The role of common variation of GCK is uncertain. A polymorphism at position -30 of the GCK beta-cell-specific promoter, present in 30% of the population, has been variably associated with type 2 diabetes and diabetes-related quantitative traits. Using 1,763...
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