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Article

Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein.

Clinical pharmacology and therapeutics - 1 Jan 2007

de Jong F A, Scott-Horton T J, Kroetz D L, McLeod H L, Friberg L E, Mathijssen R H, Verweij J, Marsh S, Sparreboom A

Abstract excerpt

Interindividual pharmacokinetic variability of the anticancer agent irinotecan is high. Life-threatening diarrhea is observed in up to 25% of patients receiving irinotecan and has been related with irinotecan pharmacokinetics and UGT1A1 genotype status. Here, we explore the association of ABCC2 (MRP2) polymorphisms and haplotypes with irinotecan disposition and diarrhea. A cohort of 167 Caucasian cancer patients...

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Source

Identifiers

PMID: 17185998
DOI: 10.1038/sj.clpt.6100019

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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