Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI).

doi:10.1248/bpb.31.2137

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Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI).

Biological & pharmaceutical bulletin - 1 Nov 2008

Fujita Ken-ichi, Nagashima Fumio, Yamamoto Wataru, Endo Hisashi, Sunakawa Yu, Yamashita Keishi, Ishida Hiroo, Mizuno Keiko, Matsunaga Mototsugu, Araki Kazuhiro, Tanaka Ryuhei, Ichikawa Wataru, Miya Toshimichi, Narabayashi Masaru, Akiyama Yuko, Kawara Kaori, Ando Yuichi, Sasaki Yasutsuna

Abstract excerpt

ATP-binding cassette, sub-family C, number 2 (ABCC2) is involved in the biliary excretion of irinotecan and its metabolites, SN-38 and SN-38 glucuronide. Effects of the ABCC2 genotype on the pharmacokinetics (PK) of irinotecan and the metabolites were examined in Japanese patients with metastatic colorectal cancer receiving irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI). ABCC2 genotypes (-1549G>A,...

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PMID: 18981587
DOI: 10.1248/bpb.31.2137

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ABCC2

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