Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential

21 Dec 2006

Abstract excerpt

Human hematopoietic stem cells (HSCs) exposed to cytokines in vitro rapidly divide and lose their characteristic functional properties presumably due to the alteration of a genetic program that determines the properties of an HSC. We have attempted to reverse the silencing of this HSC genetic program by the sequential treatment of human cord blood CD34(+) cells with the chromatin-modifying agents,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Immunotherapy and Immune Responses
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17185465
DOI: 10.1182/blood-2006-07-035287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potentialPMID 17185465Read ↗

Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.Semantic proximity Read ↗

Differential Effects of Epigenetic Modifiers on the Expansion and Maintenance of Human Cord Blood Stem/Progenitor CellsSemantic proximity Read ↗

Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis.Semantic proximity Read ↗

Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells.Semantic proximity Read ↗

Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal.Semantic proximity Read ↗

Expansion and preservation of the functional activity of adult hematopoietic stem cells cultured ex vivo with a histone deacetylase inhibitor.Semantic proximity Read ↗

Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells <i>in</i> <i>vivo</i>Semantic proximity Read ↗

Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment.Semantic proximity Read ↗

Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit.Semantic proximity Read ↗

Somatic Cell-Induced Hyperacetylation, But Not Hypomethylation, Positively and Reversibly Affects the Efficiency of In Vitro Cloned Blastocyst Production in CattleSemantic proximity Read ↗

The Histone Deacetylase Inhibitor Trichostatin A Derepresses the Telomerase Reverse Transcriptase (hTERT) Gene in Human CellsSemantic proximity Read ↗

IFN-γ Negatively Modulates Self-Renewal of Repopulating Human Hemopoietic Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.