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Article

Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.

Blood - 1 Jun 2004

Milhem Mohammed, Mahmud Nadim, Lavelle Donald, Araki Hiroto, DeSimone Joseph, Saunthararajah Yogen, Hoffman Ronald

Abstract excerpt

Efforts to change the fate of human hematopoietic stem cells (HSCs) and progenitor cells (HPCs) in vitro have met with limited success. We hypothesized that previously utilized in vitro conditions might result in silencing of genes required for the maintenance of primitive HSCs/HPCs. DNA methylation and histone deacetylation are components of an epigenetic program that regulates gene expression. Using...

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Identifiers

PMID: 14976039
DOI: 10.1182/blood-2003-07-2431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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