Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal.

Cytotherapy - 1 Jan 2004

Young J C, Wu S, Hansteen G, Du C, Sambucetti L, Remiszewski S, O'Farrell A-M, Hill B, Lavau C, Murray L J

Abstract excerpt

BACKGROUND: Histone deacetylases (HDAC) are associated with a variety of transcriptional repressors that control cellular differentiation and proliferation. HDAC inhibitors such as trichostatin A, trapoxin and chlamydocin could be useful tools to modulate these cellular processes. We investigated their effect on the self-renewal of hematopoietic stem cells (HSC) during ex vivo culture. METHODS: Purified murine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Peptides, Cyclic
Share to Stem Cell Factor
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Histone Deacetylases

Share to Hydroxamic Acids

Share to Interleukin-3

Share to Thy-1 Antigens

Source

Identifiers

PMID: 16146885
DOI: 10.1080/14653240410004899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal.PMID 16146885Read ↗

HDAC inhibitors: modulating leukocyte differentiation, survival, proliferation and inflammationSemantic proximity Read ↗

c-Myc inhibition is critical for HSC expansion and Rad51 expressionSemantic proximity Read ↗

Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells.Semantic proximity Read ↗

Directing cell differentiation with small-molecule histone deacetylase inhibitors: The example of promoting pancreatic endocrine cellsSemantic proximity Read ↗

Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.Semantic proximity Read ↗

Differential Effects of Epigenetic Modifiers on the Expansion and Maintenance of Human Cord Blood Stem/Progenitor CellsSemantic proximity Read ↗

Improvement of Cardiac Function in Mouse Myocardial Infarction after Transplantation of Epigenetically-Modified Bone Marrow Progenitor CellsSemantic proximity Read ↗

Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells.Semantic proximity Read ↗

Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potentialSemantic proximity Read ↗

Inactivation of histone deacetylase 1 (HDAC1) but not HDAC2 is required for the glucocorticoid-dependent CCAAT/enhancer-binding protein α (C/EBPα) expression and preadipocyte differentiation.Semantic proximity Read ↗

Success of Immunosuppressive Treatments in Patients with Chronic Graft-versus-Host DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.