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Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells <i>in</i> <i>vivo</i>

7 Mar 2003

Abstract excerpt

Human hematopoietic stem cells are defined by their ability to repopulate multiple hematopoietic lineages in the bone marrow of transplanted recipients and therefore are functionally distinct from hematopoietic progenitors detected in vitro. Although factors capable of regulating progenitors are well established, in vivo regulators of hematopoietic repopulating function are unknown. By using a member of the...

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PMID: 12626754
DOI: 10.1073/pnas.0130233100

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