Article

A195V mutation identified in sudden cardiac death decreases membrane localization and activation current density and abolishes cAMP sensitivity of HCN4 channels

2023-03-16

Abstract excerpt

Mutation A195V in hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) channel was identified to be genetically associated with sudden unexplained nocturnal death syndrome (SUNDS) and sudden infant death syndrome (SIDS) by us and other group, respectively. However, the underlying mechanism by which this rare variant causes SUNDS and SIDS remains unknow. In this study, HEK293 cells were transfected...

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Literature Corpus work: 78a7497b-bd04-5c9a-b58d-8007235ea6a7
DOI: 10.21203/rs.3.rs-2466162/v1

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