Article
Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer.
PloS one - 20 Dec 2006
Lemjabbar-Alaoui Hassan, Dasari Vijay, Sidhu Sukhvinder S, Mengistab Aklilu, Finkbeiner Walter, Gallup Marianne, Basbaum Carol
Abstract excerpt
BACKGROUND: Lung cancer is the leading cause of cancer death in the world, and greater than 90% of lung cancers are cigarette smoke-related. Current treatment options are inadequate, because the molecular basis of cigarette-induced lung cancer is poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that human primary or immortalized bronchial epithelial cells exposed to cigarette smoke for eight days...
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