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Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance

19 Sept 2018

Abstract excerpt

Hedgehog signaling pathway is physiologically activated during embryogenesis, especially in lung development. It is also reactivated in many solid tumors. In lung cancer, Hedgehog pathway is closely associated with cancer stem cells (CSCs). Recent works have shown that CSCs produced a full-length Sonic Hedgehog (Shh) protein, with paracrine activity and induction of tumor development. Hedgehog pathway is also...

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PMID: 30235830
DOI: 10.3390/ijms19092835

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