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Article

The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro.

British journal of cancer - 29 Jul 2002

Riebeling C, Forsea A-M, Raisova M, Orfanos C E, Geilen C C

Abstract excerpt

Pamidronate belongs to the class of nitrogen-containing bisphosphonates that are potent inhibitors of bone resorption frequently used for the treatment of osteoporosis and cancer-induced osteolysis. The inhibition of osteoclasts' growth has been suggested as the main mechanism of the inhibitory effect of pamidronate on bone metastases. Recent findings indicated that bisphosphonates also have a direct apoptotic...

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Identifiers

PMID: 12177810
DOI: 10.1038/sj.bjc.6600476
PMCID: PMC2364216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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