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Article

Histone Deacetylase Inhibitors Induce Growth Arrest and Differentiation in Uveal Melanoma

28 Oct 2011

Abstract excerpt

PURPOSE: Metastasis is responsible for the death of most cancer patients, yet few therapeutic agents are available which specifically target the molecular events that lead to metastasis. We recently showed that inactivating mutations in the tumor suppressor gene BAP1 are closely associated with loss of melanocytic differentiation in uveal melanoma (UM) and metastasis. The purpose of this study was to identify...

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PMID: 22038994
DOI: 10.1158/1078-0432.ccr-11-0946

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