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Article

AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells.

Anti-cancer drugs - 1 Aug 2015

Carpi Sara, Fogli Stefano, Romanini Antonella, Pellegrino Mario, Adinolfi Barbara, Podestà Adriano, Costa Barbara, Da Pozzo Eleonora, Martini Claudia, Breschi Maria Cristina, Nieri Paola

Abstract excerpt

Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer. AM251 is a cannabinoid type 1 (CB1) receptor antagonist/inverse agonist with off-target antitumor activity against pancreatic and colon cancer cells. The current study aimed to characterize the in-vitro antimelanoma activity of AM251. The BRAF V600E mutant melanoma cell line, A375, was used as an in-vitro model system....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25974027
DOI: 10.1097/CAD.0000000000000246

Genes

BAX
BCL2
BRAF
GPR55
TRPA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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