Article
Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension.
Clinical pharmacology and therapeutics - 1 Dec 2006
Iaccarino Guido, Izzo Raffaele, Trimarco Valentina, Cipolletta Ersilia, Lanni Francesca, Sorriento Daniela, Iovino Gianni Luigi, Rozza Francesco, De Luca Nicola, Priante Ornella, Di Renzo Gianfranco, Trimarco Bruno
Abstract excerpt
OBJECTIVES: Although blood pressure is considered the major determinant of left ventricular hypertrophy in hypertension, genetic variability is increasingly being considered among the factors influencing this complication. beta(2)-Adrenergic receptors (beta(2)ARs) are up-regulated in hypertension and largely polymorphic within the human population. Recently, we have shown that the Glu27 beta(2)AR variant is...
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