Article
The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension.
Journal of hypertension - 1 Nov 2004
Iaccarino Guido, Lanni Francesca, Cipolletta Ersilia, Trimarco Valentina, Izzo Raffaele, Iovino Gianni Luigi, De Luca Nicola, Trimarco Bruno
Abstract excerpt
OBJECTIVE: Cardiac and vascular remodeling occur in response to hypertension. Genetic background appears to modify the development of target organ damage (TOD). We evaluated the impact on hypertension-associated TOD of a highly polymorphic gene with elevated significance for the regulation of the cardiovascular system, the beta2AR gene. METHODS: We recruited 775 hypertensives (mean +/- SE: age 53.5 +/- 0.5, from...
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