Article
Association of the maternal 14-bp insertion polymorphism in the HLA-G gene in women with recurrent spontaneous abortions.
Tissue antigens - 1 Dec 2006
Yan W H, Lin A, Chen X J, Dai M Z, Gan L H, Zhou M Y, Zhu M, Shi W W, Liu J M
Abstract excerpt
Human leukocyte antigen (HLA)-G has been postulated as an important immunotolerant molecule in maintaining fetal-maternal relationship. Recent reports indicated that the 14-bp deletion/insertion polymorphism in exon 8 of HLA-G gene influences HLA-G mRNA stability and isoform splicing patterns, thus modulating the levels of HLA-G expression. This might play an immunomodulatory role of HLA-G during implantation and...
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