Article
In-frame triplet deletions in RHD alter the D antigen phenotype.
Transfusion - 1 Dec 2006
Flegel Willy A, Eicher Nicole I, Doescher Andrea, Hustinx Hein, Gowland Peter, Mansouri Taleghani Behrouz, Petershofen Eduard K, Bauerfeind Ursula, Ernst Manfred, von Zabern Ingeborg, Schrezenmeier Hubert, Wagner Franz F
Abstract excerpt
BACKGROUND: The deletion of three adjacent nucleotides in an exon may cause the lack of a single amino acid, while the protein sequence remains otherwise unchanged. Only one such in-frame deletion is known in the two RH genes, represented by the RHCE allele ceBP expressing a "very weak e antigen." STUDY DESIGN AND METHODS: Blood donor samples were recognized because of discrepant results of D phenotyping. Six...
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