Article
Insights into anti-D formation in carriers of RhD variants through studies of 3D intraprotein interactions.
Transfusion - 1 Apr 2021
Floch Aline, Pirenne France, Barrault Aurélie, Chami Btissam, Toly-Ndour Cécile, Tournamille Christophe, de Brevern Alexandre G
Abstract excerpt
BACKGROUND: Many RhD variants associated with anti-D formation (partial D) in carriers exposed to the conventional D antigen carry mutations affecting extracellular loop residues. Surprisingly, some carry mutations affecting transmembrane or intracellular domains, positions not thought likely to have a major impact on D epitopes. STUDY DESIGN AND METHODS: A wild-type Rh trimer (RhD1 RhAG2 ) was modeled by...
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