Article
DCS-1, DCS-2, and DFV share amino acid substitutions at the extracellular RhD protein vestibule.
Transfusion - 1 Jan 2008
Flegel Willy A, von Zabern Inge, Doescher Andrea, Wagner Franz F, Vytisková Jindra, Písacka Martin
Abstract excerpt
BACKGROUND: RhD and RhCE are structurally related to ammonium transporter proteins, yet their physiologic function remains unclear. Recent three-dimensional homology modeling with Escherichia coli AmtB as a template defined a putative transmembraneous channel. Three RhD variants with amino acid substitutions located at the extracellular channel aperture are described. STUDY DESIGN AND METHODS: Blood samples were...
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