Article
The 61 A/G EGF polymorphism is functional but is neither a prognostic marker nor a risk factor for glioblastoma.
Cancer genetics and cytogenetics - 1 Jan 2007
Vauleon Elodie, Auger Nathalie, Benouaich-Amiel Alexandra, Laigle-Donadey Florence, Kaloshi Gentian, Lejeune Julie, Delattre Jean-Yves, Thillet Joëlle, Sanson Marc
Abstract excerpt
The A/G61 polymorphism located in the 5'UTR of the EGF gene has been found to be both a risk factor and a prognostic factor in glioblastoma (GBM), but the functional consequences have not been investigated. Here we show, in vitro, that this polymorphism is functional, in that the G allele promoter is 40% more active than the A variant (P < 0.001). However, analysis of a large series of 209 GBM patients and 214...
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