Epitope mapping of human monoclonal antibodies to HLA-B27 by using natural and mutated antigenic variants.

doi:10.1016/0198-8859(91)90099-u

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Article

Epitope mapping of human monoclonal antibodies to HLA-B27 by using natural and mutated antigenic variants.

Human immunology - 1 Aug 1991

Weyl D, Hansen T, Deschamps Y, Hannestad K, Toubert A

Abstract excerpt

The epitopes defined by three human monoclonal antibodies (mAbs) (Tr3B6, TrCG10, TrBH12) against HLA-B27 have been mapped by flow cytometry. For this purpose we used murine transfected cells expressing at their surface hybrid antigens between HLA-B7 and -B27 and, in addition, Epstein-Barr virus c...

Topics

Alleles
Animals
Antibodies, Monoclonal
Antigenic Variation
Epitopes
Female
Flow Cytometry
Gene Expression
HLA-B27 Antigen
HLA-B7 Antigen
Herpesvirus 4, Human
Humans
Mice
Mutagenesis, Insertional
Transfection
Tumor Cells, Cultured

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