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Article

Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38.

The Journal of biological chemistry - 2 Oct 2009

Graeff Richard, Liu Qun, Kriksunov Irina A, Kotaka Masayo, Oppenheimer Norman, Hao Quan, Lee Hon Cheung

Abstract excerpt

Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes that catalyze the synthesis and hydrolysis of cyclic ADP-ribose (cADPR), a Ca(2+) messenger molecule responsible for regulating a wide range of cellular functions. Although both use NAD as a substrate, the cyclase produces cADPR, whereas CD38 produces mainly ADP-ribose (ADPR). To elucidate the catalytic differences...

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Identifiers

PMID: 19640843
DOI: 10.1074/jbc.M109.030965
PMCID: PMC2785691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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