Article
A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca2+ signaling via CD38/ADP-ribosyl cyclase, a putative intracellular NAD+ sensor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2002
Sun Li, Adebanjo Olugbenga A, Koval Anatoliy, Anandatheerthavarada Hindupur K, Iqbal Jameel, Wu Xing Y, Moonga Baljit S, Wu Xue B, Biswas Gopa, Bevis Peter J R, Kumegawa Masoyoshi, Epstein Solomon, Huang Christopher L-H, Avadhani Narayan G, Abe Etsuko, Zaidi Mone
Abstract excerpt
CD38 is an ectocyclase that converts NAD+ to the Ca2+-releasing second messenger cyclic ADP-ribose (cADPr). Here we report that in addition to CD38 ecto-catalysis, intracellularly expressed CD38 may catalyze NAD+-->cADPr conversion to cause cytosolic Ca2+ release. High levels of CD38 were found in the plasma membranes, endoplasmic reticulum, and nuclear membranes of osteoblastic MC3T3-E1 cells. More important,...
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