Article
Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.
Neuron - 1 Dec 1998
Fox J W, Lamperti E D, Ekşioğlu Y Z, Hong S E, Feng Y, Graham D A, Scheffer I E, Dobyns W B, Hirsch B A, Radtke R A, Berkovic S F, Huttenlocher P R, Walsh C A
Abstract excerpt
Long-range, directed migration is particularly dramatic in the cerebral cortex, where postmitotic neurons generated deep in the brain migrate to form layers with distinct form and function. In the X-linked dominant human disorder periventricular heterotopia (PH), many neurons fail to migrate and persist as nodules lining the ventricular surface. Females with PH present with epilepsy and other signs, including...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.