Article
Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.
Neuron - 1 Dec 1998
Fox J W, Lamperti E D, Ekşioğlu Y Z, Hong S E, Feng Y, Graham D A, Scheffer I E, Dobyns W B, Hirsch B A, Radtke R A, Berkovic S F, Huttenlocher P R, Walsh C A
Abstract excerpt
Long-range, directed migration is particularly dramatic in the cerebral cortex, where postmitotic neurons generated deep in the brain migrate to form layers with distinct form and function. In the X-linked dominant human disorder periventricular heterotopia (PH), many neurons fail to migrate and...
Topics
- Abnormalities, Multiple
- Aging
- Animals
- Brain
- Brain Diseases
- Cerebral Cortex
- Cerebral Ventricles
- Choristoma
- Chromosome Mapping
- Contractile Proteins
- Embryonic and Fetal Development
- Epilepsy
- Female
- Fetal Death