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Article

Filamin A: phenotypic diversity.

Current opinion in genetics & development - 1 Jun 2005

Robertson Stephen P

Abstract excerpt

Filamins cross-link the actin cytoskeleton into orthogonal networks and modulate the response of cells to their chemical and mechanical environment by regulating changes in shape and motility. Null mutations in FLNA, the gene that encodes filamin A, lead to defects in neuronal migration, vascular function and connective tissue integrity. By contrast, missense mutations in this same gene produce a spectrum of...

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Source

Identifiers

PMID: 15917206
DOI: 10.1016/j.gde.2005.04.001

Genes

FLNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Filamin A: phenotypic diversity.PMID 15917206Read ↗

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The X-linked filaminopathies: Synergistic insights from clinical and molecular analysis.Semantic proximity Read ↗

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Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders†Semantic proximity Read ↗

Filamin A in focus: unravelling the multifaceted roles of filamin A in neurodevelopment and neurological disordersSemantic proximity Read ↗

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