Spindle checkpoint function and cellular sensitivity to antimitotic drugs

Abstract excerpt

Microtubule inhibitors such as Vinka alkaloids (e.g., vinblastine and vincristine) and Taxans (e.g., taxol/paclitaxel and docetaxel) are potent therapeutic drugs for cancer treatment. The cellular consequences of taxol/paclitaxel treatments over a wide range of doses (1 nmol/L–100 μmol/L) have been reported. Overall, the main target of clinically relevant, low-to-moderate doses of taxol (5–200 nmol/L) is the...

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