Article
Characterization of a large Lebanese family segregating IgA nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2007
Karnib Hussein H, Sanna-Cherchi Simone, Zalloua Pierre A, Medawar Walid, D'Agati Vivette D, Lifton Richard P, Badr Kamal, Gharavi Ali G
Abstract excerpt
BACKGROUND: Familial aggregation of IgA nephropathy (IgAN) suggests that genetic factors contribute to the development of this trait. Because clinical manifestations in IgAN families are often limited to episodic haematuria, large kindreds tractable to linkage analysis have been difficult to identify. METHODS: We identified a large Lebanese-Druze kindred ascertained via an index case with biopsy-documented IgAN....
Topics
- Adolescent
- Adult
- Aged
- Biopsy
- Child
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Glomerulonephritis, IGA
- Hematuria
- Humans
- Incidence
- Infectious Disease Transmission, Vertical