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Article

Improved growth of enteric adenovirus type 40 in a modified cell line that can no longer respond to interferon stimulation

15 Dec 2006

Abstract excerpt

Human enteric adenoviruses propagate poorly in conventional human cell lines used to grow other adenovirus serotypes. As human enteric adenoviruses have a defect in counteracting the cellular interferon (IFN) response in cell culture, to aid in growth of the virus, a 293-based cell line defective in its ability to respond to IFN was constructed. This cell line (293-SV5/V) constitutively expresses V-protein of the...

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PMID: 17170438
DOI: 10.1099/vir.0.82445-0

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