Article
Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: the multifunctional V protein blocks both interferon-beta induction and interferon signaling.
Virology - 10 Nov 2002
He Biao, Paterson Reay G, Stock Nicola, Durbin Joan E, Durbin Russell K, Goodbourn Stephen, Randall Richard E, Lamb Robert A
Abstract excerpt
The V protein of the Paramyxovirus simian virus 5 (SV5) is a multifunctional protein containing an N-terminal 164 residue domain that is shared with the P protein and a distinct C-terminal domain that is cysteine-rich and which is highly conserved among Paramyxoviruses. We report the recovery from Vero cells [interferon (IFN) nonproducing cells] of a recombinant SV5 (rSV5) that lacks the V protein C-terminal...
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