Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protease-Deleted Adenovirus Vectors and Complementing Cell Lines: Potential Applications of Single-Round Replication Mutants for Vaccination and Gene Therapy

10 Jun 2000

Abstract excerpt

A new kind of versatile adenoviral vector (AdV) has been constructed, one that is completely replication disabled in the absence of Ad-E1 proteins but is capable of a single round of replication when Ad-E1 is present. This was made possible by deletion of the Ad protease gene (PS), which is essential for many steps of the Ad life cycle. The PS-deleted virus can be propagated in 293-derived cell lines engineered...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10890743
DOI: 10.1089/10430340050032438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protease-Deleted Adenovirus Vectors and Complementing Cell Lines: Potential Applications of Single-Round Replication Mutants for Vaccination and Gene TherapyPMID 10890743Read ↗

Improved adenovirus packaging cell lines to support the growth of replication-defective gene-delivery vectors.Semantic proximity Read ↗

Advances in adenoviral vectors: from genetic engineering to their biologySemantic proximity Read ↗

Adenoviral Producer CellsSemantic proximity Read ↗

A simplified system for generating recombinant adenovirusesSemantic proximity Read ↗

Evolving Horizons: Adenovirus Vectors’ Timeless Influence on Cancer, Gene Therapy and VaccinesSemantic proximity Read ↗

Serum‐free transient protein production system based on adenoviral vector and PER.C6 technology: High yield and preserved bioactivitySemantic proximity Read ↗

Large-Scale Production of High-Quality Helper-Dependent Adenoviral Vectors Using Adherent Cells in Cell FactoriesSemantic proximity Read ↗

A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4Semantic proximity Read ↗

An Enhanced System for Construction of Adenoviral Vectors by the Two-Plasmid Rescue MethodSemantic proximity Read ↗

A Novel Gene Expression Control System and Its Use in Stable, High-Titer 293 Cell-Based Adeno-Associated Virus Packaging Cell LinesSemantic proximity Read ↗

Designer Oncolytic Adenovirus: Coming of AgeSemantic proximity Read ↗

Retargeting adenoviruses for therapeutic applications and vaccinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.