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Article

Antithrombotic and anticoagulant effects of wild type and Gla-domain mutated human activated protein C in rats.

Thrombosis research - 1 Jan 2007

Malm Karl, Arnljots Björn, Persson Ing-Marie, Dahlbäck Björn

Abstract excerpt

The antithrombotic and anticoagulant effects of recombinant wild type (WT) and mutated human activated protein C (hAPC) were investigated using a rat model of arterial thrombosis. Recent in vitro studies using human plasma have shown enhanced anticoagulant effects of hAPC by mutagenesis of either loop 148 in the serine protease domain or of the Gla domain. The Gla-domain mutant QGNSEDY-hAPC (=...

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Share to Anticoagulants
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

Share to Rats, Sprague-Dawley

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Source

Identifiers

PMID: 17169412
DOI: 10.1016/j.thromres.2006.11.004

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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