Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calmodulin Methyltransferase Is Required for Growth, Muscle Strength, Somatosensory Development and Brain Function

6 Aug 2015

Abstract excerpt

Calmodulin lysine methyl transferase (CaM KMT) is ubiquitously expressed and highly conserved from plants to vertebrates. CaM is frequently trimethylated at Lys-115, however, the role of CaM methylation in vertebrates has not been studied. CaM KMT was found to be homozygously deleted in the 2P21 deletion syndrome that includes 4 genes. These patients present with cystinuria, severe intellectual disabilities,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Folate and B Vitamins Research
Share to Genetics and Neurodevelopmental Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26247364
DOI: 10.1371/journal.pgen.1005388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calmodulin Methyltransferase Is Required for Growth, Muscle Strength, Somatosensory Development and Brain FunctionPMID 26247364Read ↗

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.Semantic proximity Read ↗

Human Calmodulin MutationsSemantic proximity Read ↗

CAMTA1-related disorder: Phenotypic and molecular characterization of 26 new individuals and literature review.Semantic proximity Read ↗

Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.Semantic proximity Read ↗

Phenotypic expansion of CALM1/2-associated disorders to include neurologic phenotypes without arrhythmia.Semantic proximity Read ↗

Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.Semantic proximity Read ↗

Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms.Semantic proximity Read ↗

Severe intellectual disability, absence of language, epilepsy, microcephaly and progressive cerebellar atrophy related to the recurrent de novo variant p.(P139L) of the CAMK2B gene: A case report and brief review.Semantic proximity Read ↗

Myoclonic dystonia phenotype related to a novel calmodulin-binding transcription activator 1 sequence variant.Semantic proximity Read ↗

Gap Junction Channelopathies and Calmodulinopathies. Do Disease-Causing Calmodulin Mutants Affect Direct Cell-Cell Communication?Semantic proximity Read ↗

A clustered regularly interspaced short palindromic repeats knockout method to reveal methyl-CpG binding domain 4 functionSemantic proximity Read ↗

crv4, a mouse model for human ataxia associated with kyphoscoliosis caused by an mRNA splicing mutation of the metabotropic glutamate receptor 1 (Grm1).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.