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Article

Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.

Current Alzheimer research - 1 Dec 2006

Cruts Marc, Kumar-Singh Samir, Van Broeckhoven Christine

Abstract excerpt

Two genetically distinct types of frontotemporal dementia (FTD) are linked to chromosome 17q21. FTD with parkinsonism (FTDP-17) results from mutations in the gene encoding microtubule associated protein tau (MAPT) and is associated with tau deposition in the patient's brain. An increasing number of FTD families are linked to 17q21 in the absence of a demonstrable MAPT mutation. Brains of these patients do not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17168647
DOI: 10.2174/156720506779025251

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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