Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.

doi:10.1038/nature05016

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Article

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.

Nature - 24 Aug 2006

Baker Matt, Mackenzie Ian R, Pickering-Brown Stuart M, Gass Jennifer, Rademakers Rosa, Lindholm Caroline, Snowden Julie, Adamson Jennifer, Sadovnick A Dessa, Rollinson Sara, Cannon Ashley, Dwosh Emily, Neary David, Melquist Stacey, Richardson Anna, Dickson Dennis, Berger Zdenek, Eriksen Jason, Robinson Todd, Zehr Cynthia, Dickey Chad A, Crook Richard, McGowan Eileen, Mann David, Boeve Bradley, Feldman Howard, Hutton Mike

Abstract excerpt

Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. A large proportion of FTD patients (35-50%) have a family history of dementia, consistent with a strong genetic component to the disease. In 1998, mutations in the gene encoding the microtubule-associated protein tau (MAPT) were shown to cause familial FTD with parkinsonism linked to chromosome 17q21...

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PMID: 16862116
DOI: 10.1038/nature05016

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MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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