Article
A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17.
Brain : a journal of neurology - 1 Apr 2006
Mackenzie Ian R, Baker Matthew, West Gemma, Woulfe John, Qadi Najeeb, Gass Jennifer, Cannon Ashley, Adamson Jennifer, Feldman Howard, Lindholm Caroline, Melquist Stacey, Pettman Rachel, Sadovnick A Dessa, Dwosh Emily, Whiteheart Sidney W, Hutton Michael, Pickering-Brown Stuart M
Abstract excerpt
Over 30 different mutations have now been identified in MAPt that cause frontotemporal dementia (FTD). However, there are several families with FTD that show definite linkage to the region on chromosome 17 that contains MAPt, in which no mutation(s) has been identified. Although these families could have a complex mutation of the MAPt locus that has evaded detection it is also possible that another gene in this...
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