[Clinical, pathological, and genetic characteristics of frontotemporal dementia and parkinsonism linked to chromosome 17 with mutations in the MAPT and PGRN].

Abstract excerpt

We reviewed the clinical, neuropathological, and genetic findings in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) with mutations in microtubule-associated protein tau (MAPT) and progranulin (PGRN). Research on FTDP-17 has greatly progressed over the years. Clinically, FTDP-17 is clinically characterized by autosomal dominant frontotemporal dementia, with or without...

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