Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22

Abstract excerpt

Hereditary frontotemporal dementia (FTD) is an autosomal dominant neurodegenerative disorder that is associated with mutations in the tau gene and with the pathological accumulation of hyperphosphorylated tau protein in affected brain cells in about a quarter of cases. However, most FTD families have no demonstrable tau mutations. Here we describe the clinical and neuropathological features of a large family with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Amyotrophic Lateral Sclerosis Research
• Share to Parkinson's Disease Mechanisms and Treatments