Article
Interferon inhibition of neoplastic phenotype in cell lines harbouring human papillomavirus sequences.
Journal of biological regulators and homeostatic agents - 1 Jan 2000
De Marco F, Di Lonardo A, Venuti A, Marcante M L
Abstract excerpt
The transformed phenotype is markedly affected by Interferon (IFN) long term treatment in HeLa and Siha cell lines. Two months of continuous exposure to 100 and 1000 International Units (IU)/ml of human recombinant alpha IFN causes a drastic reduction of anchorage independent growth in soft-agar....
Topics
- Cell Division
- DNA, Viral
- Genes, Viral
- Genes, p53
- HeLa Cells
- Humans
- Interferons
- Neoplastic Stem Cells
- Papillomaviridae
- Phenotype