Article
[Association between tumor necrosis factor-alpha promoter polymorphisms and type 2 diabetes and obesity in Chilean elderly women].
Revista medica de Chile - 1 Sept 2006
Santos M José Luis, Patiño G Ana, Angel B Bárbara, Martínez H José Alfredo, Pérez B Francisco, Villarroel B Ana Claudia, Sierrasesúmaga A Luis, Albala B Cecilia
Abstract excerpt
BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) has an increased expression in the adipose tissue of obese subjects and is involved in insulin resistance. AIM: To screen for associations between -308G/A, -238G/A, -376G/A and -163G/A genetic variants of the TNF-alpha gene, diabetes and obesity-related variables. MATERIAL AND METHODS: A group of 263 elderly women aged 60-90 years were recruited. Among them, an...
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