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Article

Association between anthropometric measures of obesity, metabolic disturbances and polymorphism G-308A of the tumor necrosis factor-alpha gene in children.

European journal of medical research - 4 Nov 2010

Pyrzak Beata, Wisniewska A, Popko K, Demkow U, Kucharska A M

Abstract excerpt

INTRODUCTION: TNF--α is one of the most important factors in the development and course of inflammation. It is suggested that polymorphism located in the 5'regulatory region of the TNF-α gene at position 308 (guanine [G]→adenine[A]) may increase the expression of this cytokine in fat tissue and i...

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Identifiers

PMID: 21147642
DOI: 10.1186/2047-783x-15-s2-141
PMCID: PMC4360278

Genes

TNF
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21147642-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Association between anthropometric measures of obesity, metabolic disturbances and polymorphism G-308A of the tumor necrosis factor-alpha gene in children.PMID 21147642Read ↗

[Tumor necrosis factor alpha (TNF-alpha) gene G-308A polymorphism relationship to insulin resistance and lipid abnormalities in children with obesity].Semantic proximity Read ↗

The impact of TNF-α 308G>A gene polymorphism on children's overweight risk and an assessment of biochemical variables: A cross-sectional single-center experience.Semantic proximity Read ↗

Association of TNF-α promoter gene G-308A polymorphism with metabolic syndrome, insulin resistance, serum TNF-α and leptin levels in Indian adult women.Semantic proximity Read ↗

Association between TNF-α promoter G-308A and G-238A polymorphisms and obesity.Semantic proximity Read ↗

Risk of obesity and type 2 diabetes with tumor necrosis factor-α 308G/A gene polymorphism in metabolic syndrome and coronary artery disease subjects.Semantic proximity Read ↗

Association of TNF-α-308 G>A (rs1800629) polymorphism with susceptibility of metabolic syndromeSemantic proximity Read ↗

Influence of IL-10, IL-6 and TNF-α gene polymorphism on obesity.Semantic proximity Read ↗

Allelic frequency of G380A polymorphism of tumor necrosis factor alpha gene and relation with cardiovascular risk factors and adipocytokines in obese patients.Semantic proximity Read ↗

Association between toll-like receptor polymorphisms and serum levels of tumor necrosis factor-alpha and its soluble receptors in obese children.Semantic proximity Read ↗

The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome.Semantic proximity Read ↗

Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome.Semantic proximity Read ↗

Tumor necrosis factor-alpha--308 G/A polymorphism in obese Caucasians.Semantic proximity Read ↗

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