Article
Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men.
Metabolism: clinical and experimental - 1 Dec 2000
Ishii T, Hirose H, Saito I, Nishikai K, Maruyama H, Saruta T
Abstract excerpt
In obese subjects, the levels of tumor necrosis factor alpha (TNF-alpha) expression and protein synthesis in adipocytes are increased. A recent study of Caucasians suggested that the TNF-alpha gene promoter region polymorphism at position -308 influences insulin resistance and percent body fat and increases serum leptin levels, although conflicting data are also reported. The present study was performed to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.