Nonhuman genetics. Strong male bias drives germline mutation in chimpanzees.

Abstract excerpt

Germline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10(-8) per base pair per generation, with every additional year of father's age contributing two mutations across the genome and males contributing three to four times as many mutations as females. To assess whether such patterns are shared with our closest living...

Topics

• Animals
• Chromosome Mapping
• Evolution, Molecular
• Female
• Genetic Variation
• Germ-Line Mutation
• Male
• Models, Genetic
• Models, Statistical
• Pan troglodytes
• Pedigree