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Chronic Pseudomonas aeruginosa infection reduces surfactant levels by inhibiting its biosynthesis.

Cellular microbiology - 1 Apr 2007

Wu Yanghong, Xu Zhiwei, Henderson Florita C, Ryan Alan J, Yahr Timothy L, Mallampalli Rama K

Abstract excerpt

Chronic Pseudomonas aeruginosa infection, as occurs in cystic fibrosis, is associated with decreased surfactant phospholipid levels. To investigate mechanisms, we measured synthesis of dipalmitoylphosphatidylcholine (DPPC), the major surfactant phospholipid. Mice received an agarose bead slurry a...

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PMID: 17166234
DOI: 10.1111/j.1462-5822.2006.00852.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17166234-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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