Article
Pulmonary dehydration and infection in cystic fibrosis: evidence that ethanol activates alginate gene expression and induction of mucoidy in Pseudomonas aeruginosa.
Molecular microbiology - 1 May 1990
DeVault J D, Kimbara K, Chakrabarty A M
Abstract excerpt
Mortality among cystic fibrosis (CF) patients is most commonly attributed to pulmonary infection by mucoid, alginate-producing Pseudomonas aeruginosa. The initial infecting P. aeruginosa are typically non-mucoid; however, upon continued exposure to the CF lung environment, they become highly muco...
Topics
- Alginates
- Cystic Fibrosis
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Ethanol
- Gene Expression Regulation, Bacterial
- Humans
- Lung
- Mucoproteins
- Mutation
- Promoter Regions, Genetic
- Transcriptional Activation