Article
Glucose-induced production of recombinant proteins in Hansenula polymorpha mutants deficient in catabolite repression.
Biotechnology and bioengineering - 1 Jul 2007
Krasovska Olena S, Stasyk Olena G, Nahorny Viktor O, Stasyk Oleh V, Granovski Nikolai, Kordium Vitaliy A, Vozianov Oleksandr F, Sibirny Andriy A
Abstract excerpt
The most commonly used expression platform for production of recombinant proteins in the methylotrophic yeast Hansenula polymorpha relies on the strong and strictly regulated promoter from the gene encoding peroxisomal enzyme alcohol (or methanol) oxidase (P(MOX)). Expression from P(MOX) is induced by methanol and is partially derepressed in glycerol or xylose medium, whereas in the presence of hexoses,...
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