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Article

Efficient bioconversion of ethanol to acetaldehyde using a novel mutant strain of the methylotrophic yeast Hansenula polymorpha.

Biotechnology and bioengineering - 5 Apr 2000

Moroz O M, Gonchar M V, Sibirny A A

Abstract excerpt

We report the isolation of mutant strains of the methylotrophic yeast Hansenula polymorpha that are able to efficiently oxidize ethanol to acetaldehyde in an intact cell system. The oxidation reaction is catalyzed by alcohol oxidase (AOX), a key enzyme in the methanol metabolic pathway that is typically present only in H. polymorpha cells growing on methanol. At least three mutations were introduced in the...

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PMID: 10699870
DOI: 10.1002/(sici)1097-0290(20000405)68:1<44::aid-bit5>3.0.co;2-8

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