Article
Mutation, replicative infidelity of DNA and aneuploidy sequentially in the formation of malignant pleomorphic tumors.
Histology and histopathology - 1 Mar 2007
Bignold L P
Abstract excerpt
Mutations are thought to be involved in tumor formation because (i) tumor cells transmit their abnormalities to their descendants; and (ii) many carcinogens are mutagens. Aneuploidy is thought to be involved in tumor formation because (i) it is a common phenomenon, especially among malignant neoplasms; (ii) certain particular types of tumors are associated with specific karyotypic changes; and (iii) many immortal...
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