Article
Immunosuppressive activity of recombinant ILT3.
International immunopharmacology - 20 Dec 2006
Vlad George, Liu Zhuoru, Zhang Qing-Yin, Cortesini Raffaello, Suciu-Foca Nicole
Abstract excerpt
Tolerogenic antigen presenting cells (APC) are characterized by high expression of the inhibitory receptors ILT3 and ILT4. We have engineered ILT3 and ILT4 cytoplasmic deletion mutants (ILT3delta and ILT4delta), which were transfected in the dendritic-like cell line KG1, to investigate ILT3 and ILT4's capacity to signal extracellularly. KG1.ILT3delta, similar to untruncated ILT3, inhibits T cell responses such as...
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